Xilometazolin

Xilometazolin
Data klinis
Palafalan	/ˌzaɪloʊˌmɛtəˈzoʊliːn/;
Namo dagang	Otrivin, Otrivine, others
AHFS/Drugs.com	Monograph
MedlinePlus	a608026
Lisensi data	US DailyMed: Xylometazoline;
Kategori pado kahamilan	C;
Kacondongan; katagantuangan	Moderate
Rute; masuak ubek	intranasal (spray or drops)
Kelas ubek	α1 and α2 adrenergic receptor agonist
Kode ATC	R01AA07 (WHO) S01GA03 (WHO);
Status legal
Status legal	In general: Over-the-counter (OTC);
Farmakokinetik data
Eliminasi wakatu paruah	>10 seconds
Ekskresi	Urinary
Pangenal
	Namo IUPAC 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-; 4,5-dihydro-1H-imidazole
Nomor CAS	526-36-3 ;
PubChem CID	5709;
IUPHAR/BPS	517;
DrugBank	DB06694 ;
ChemSpider	5507 ;
UNII	WPY40FTH8K;
KEGG	D08684 ;
ChEMBL	ChEMBL312448 ;
CompTox Dashboard (EPA)	DTXSID8046957 ;
ECHA InfoCard	100.007.629
Data kimia jo fisika
Formula	C16H24N2
Molar mass	244.382 g·mol−1
3D model (JSmol)	Gambar interaktif;
	SMILES N\1=C(\NCC/1)Cc2c(cc(cc2C)C(C)(C)C)C
	InChI InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18) ; Key:HUCJFAOMUPXHDK-UHFFFAOYSA-N
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Xilometazolin adolah bahan aktif nan ado pado ubek semprot hiduang digunokan untuak maradokan hiduang nan tasumbek ^[1]

Deskripsi

Xilometazolin marupokan ubek dalam bantuak semprot atau tetes di hiduang nan digunokan untuak maradokan paradangan jo hiduang nan tasumbek. Ubek iko tamasuak jinih ubek dekongestan nasal nan bakarajo jo caro mangikek reseptor nan samo takah adrenalin. Bahan nan ado pado ubek ko mangikek reseptor alfa-adregenik untuak mangaktifkan sistem adrenal nan manyababkan vasokontriksi sistemik sahinggo mangurangi panyumbatan pado salaput lendir hiduang.^[2]

Namo jo Identifikasi

Namo IUPAC : 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole^[3]
Namo InChl : InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)^[3]
InChl Key : HUCJFAOMUPXHDK-UHFFFAOYSA-N^[3]
Canonical SMILES : CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C^[3]
Rumus Molekul : C₁₆H₂₄N₂^[3]
Nomor CAS : 526-36-3^[3]
Nomor EC (European Community : 208-390-6^[3]

Sinonim

Ba 11391^[4]
Ba-11391^[4]
BRN 0180542^[4]
EINECS 208-390-6^[4]
Otriven^[4]
Otrivin^[4]
Otrivine^[4]
Otrix^[4]
UNII-WPY40FTH8K^[4]
Xilometazolina^[4]
Xylometazolina^[4]
Xylometazolinum^[4]
Xylomethazoline^[4]

Rujuakan

↑ Ghelani, Rita (2019-11-05). "Otrivine adult nasal spray (xylometazoline)". Netdoctor (dalam bahasa Inggris). Diakses tanggal 2021-07-26. ^{[pranala nonaktif permanen]}
↑ "Xylometazoline". www.drugbank.ca. Diakses tanggal 2020-02-17.
↑ ^a ^b ^c ^d ^e ^f ^g PubChem. "Xylometazoline". pubchem.ncbi.nlm.nih.gov (dalam bahasa Inggris). Diakses tanggal 2020-02-17.
↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Drug Information Portal - Mobile - U.S. National Library of Medicine - Drug Search Results". druginfo.nlm.nih.gov. Diakses tanggal 2020-02-19.

[1] Ghelani, Rita (2019-11-05). "Otrivine adult nasal spray (xylometazoline)". Netdoctor (dalam bahasa Inggris). Diakses tanggal 2021-07-26. ^{[pranala nonaktif permanen]}

[2] "Xylometazoline". www.drugbank.ca. Diakses tanggal 2020-02-17.

[:0-3] ↑ ^a ^b ^c ^d ^e ^f ^g PubChem. "Xylometazoline". pubchem.ncbi.nlm.nih.gov (dalam bahasa Inggris). Diakses tanggal 2020-02-17.

[:3-4] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m "Drug Information Portal - Mobile - U.S. National Library of Medicine - Drug Search Results". druginfo.nlm.nih.gov. Diakses tanggal 2020-02-19.

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