Trimetoprim

Trimetoprim
Data klinis
Palafalan	/traɪˈmɛθəprɪm/
Namo dagang	Proloprim, Monotrim, Triprim, dan lain-lain
AHFS/Drugs.com	Monograph
MedlinePlus	a684025
Lisensi data	US FDA: Trimethoprim;
Kategori pado kahamilan	AU: B3 ; US: C (Risk not ruled out) ;
Rute; masuak ubek	Oral (muluik)
Kode ATC	J01EA01 (WHO) Templat:ATCvet;
Status legal
Status legal	AU: S4 (Hanyo jo resep) ; CA: ℞-only ; UK: POM (Jo resep dotor) ; US: ℞-only ;
Farmakokinetik data
Bioavailabilitas	90–100%
Ikatan protein	44%
Metabolisme	Hati
Eliminasi wakatu paruah	8-12 jam
Ekskresi	Kajamban (50–60%), feses (4%)
Pangenal
	Namo IUPAC 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine;
Nomor CAS	738-70-5 ;
PubChem CID	5578;
DrugBank	DB00440 ;
ChemSpider	5376 ;
UNII	AN164J8Y0X;
KEGG	D00145 ;
ChEBI	CHEBI:45924 ;
ChEMBL	ChEMBL22 ;
PDB ligand	TOP (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID3023712 ;
ECHA InfoCard	100.010.915
Data kimia jo fisika
Formula	C14H18N4O3
Molar mass	290.32 g/mol g·mol−1
3D model (JSmol)	Gambar interaktif;
	SMILES Nc1nc(N)ncc1Cc(cc2OC)cc(OC)c2OC;
	InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) ; Key:IEDVJHCEMCRBQM-UHFFFAOYSA-N ;
(verify)

Trimetoprim, atau namo pasarannyo Primsol,^[1] adolah antibiotik nan digunoan untuak mangatasi infeksi bakteri takah radang talingo tangah jo inpeksi saluran kamiah.^[2] Ubek ko bisa lo digunokan sarentak jo sulfametoksazol atau dapson untuak pangubatan pneumonia pneumocystis pado pandarito HIV/AIDS.^[1]^[3] Ubek ko tamasuak ka dalam Daftar Ubek Esensial Organisasi Kasihatan Dunia sabagai ciek dari banyak ubek nan paliang aman jo efektif nan diparaluan untuak sistem kasihatan.^[4]

Rujuakan

1 2 "Trimethoprim" (dalam bahasa Inggris). The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 24 September 2015.
↑ "Trimethoprim" (dalam bahasa Indonesia). Alo Dokter.
↑ Masur, H; Brooks, JT; Benson, CA; Holmes, KK; Pau, AK; Kaplan, JE; National Institutes of, Health; Centers for Disease Control and, Prevention; HIV Medicine Association of the Infectious Diseases Society of, America (Mei 2014). "Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America". Clinical Infectious Diseases. 58 (9): 1308–11. doi:10.1093/cid/ciu094. PMC 3982842 . PMID 24585567.
↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 9 Nopember 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.