Ibuprofen

Ibuprofen
Data klinis
Palafalan	/ˈaɪbjuːproʊfɛn/, /aɪbjuːˈproʊfən/,
Namo dagang	Advil, Motrin, Nurofen, others
Namo lain	isobutylphenylpropionic acid
AHFS/Drugs.com	Monograph
MedlinePlus	a682159
Lisensi data	EU EMA: by INN; US DailyMed: Ibuprofen; US FDA: Ibuprofen;
Kategori pado kahamilan	AU: C Use During Pregnancy and Breastfeeding</ref>; US: C (Risk not ruled out) ; D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus;
Rute; masuak ubek	by mouth, rectal, topical, and intravenous
Kode ATC	C01EB16 (WHO) G02CC01 (WHO) M01AE01 (WHO) M02AA13 (WHO) R02AX02 (WHO);
Status legal
Status legal	AU: OTC ; CA: OTC ; UK: General sales list (GSL, OTC) ; US: OTC / Rx-only;
Farmakokinetik data
Bioavailabilitas	80–100% (by mouth), 87% (rectal)
Ikatan protein	98%
Metabolisme	Liver (CYP2C9)
Metabolite	ibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Awitan aksi	30 min
Eliminasi wakatu paruah	2–4 h
Ekskresi	Urine (95%)
Pangenal
	Namo IUPAC (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
Nomor CAS	15687-27-1 ;
PubChem CID	3672;
IUPHAR/BPS	2713;
DrugBank	DB01050 ;
ChemSpider	3544 ;
UNII	WK2XYI10QM;
KEGG	D00126 ;
ChEBI	CHEBI:5855 ;
ChEMBL	ChEMBL521 ;
PDB ligand	IBP (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID5020732 ;
ECHA InfoCard	100.036.152
Data kimia jo fisika
Formula	C13H18O2
Molar mass	206.29 g/mol g·mol−1
3D model (JSmol)	Gambar interaktif;
Chirality	Racemic mixture
Density	1.03 g/ml g/cm3
Melting point	75 to 78 °C (167 to 172 °F)
Boiling point	157 °C (315 °F) at 4 mmHg
Solubility in water	0.021 mg/mL (20 °C)
	SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(=O)O
	InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) ; Key:HEFNNWSXXWATRW-UHFFFAOYSA-N
(verify)

Ibuprofen marupoan ubek nan digunoan untuak mangurangi raso ngilo jo paradangan, misalnyo sakik gigi, kram kutiko datang bulan, jo radang sandi. Ubek ko tasadio dalam bantuak tablet 400 mg, sirup, jo suntikan.

Rujuakan

↑ Kutipan rusak: Tag <ref> indak sah; indak ado teks untuak ref banamo Drugs.com pregnancy
↑ ^a ^b ^c Davies, NM (February 1998). "Clinical pharmacokinetics of ibuprofen. The first 30 years". Clinical Pharmacokinetics. 34 (2): 101–54. doi:10.2165/00003088-199834020-00002. PMID 9515184.
↑ Davanzo, R; Bua, J; Paloni, G; Facchina, G (November 2014). "Breastfeeding and migraine drugs". European Journal of Clinical Pharmacology (Review). 70 (11): 1313–24. doi:10.1007/s00228-014-1748-0. PMID 25217187.
↑ "ibuprofen". Diarsipkan dari versi asli tanggal 13 January 2015. Diakses tanggal 31 January 2015.
↑ Grosser, T; Ricciotti, E; FitzGerald, GA (August 2017). "The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs". Trends in Pharmacological Sciences (Review). 38 (8): 733–48. doi:10.1016/j.tips.2017.05.008. PMC 5676556 . PMID 28651847.
↑ "Brufen Tablets And Syrup". Therapeutic Goods Administration. 31 July 2012. Diarsipkan dari versi asli (PDF) tanggal 20 August 2016. Diakses tanggal 8 May 2014.

[Drugs.com_pregnancy-1] Kutipan rusak: Tag <ref> indak sah; indak ado teks untuak ref banamo Drugs.com pregnancy

[clinp-2] Davies, NM (February 1998). "Clinical pharmacokinetics of ibuprofen. The first 30 years". Clinical Pharmacokinetics. 34 (2): 101–54. doi:10.2165/00003088-199834020-00002. PMID 9515184.

[Davanzo2014-3] Davanzo, R; Bua, J; Paloni, G; Facchina, G (November 2014). "Breastfeeding and migraine drugs". European Journal of Clinical Pharmacology (Review). 70 (11): 1313–24. doi:10.1007/s00228-014-1748-0. PMID 25217187.

[4] "ibuprofen". Diarsipkan dari versi asli tanggal 13 January 2015. Diakses tanggal 31 January 2015.

[Grosser2017-5] Grosser, T; Ricciotti, E; FitzGerald, GA (August 2017). "The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs". Trends in Pharmacological Sciences (Review). 38 (8): 733–48. doi:10.1016/j.tips.2017.05.008. PMC 5676556 . PMID 28651847.

[TGA-6] "Brufen Tablets And Syrup". Therapeutic Goods Administration. 31 July 2012. Diarsipkan dari versi asli (PDF) tanggal 20 August 2016. Diakses tanggal 8 May 2014.

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