Ibuprofen

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Ibuprofen
(RS)-Ibuprofen Structural Formula V1.svg
(R)-ibuprofen
Data klinis
Palafalan/ˈbjuːprfɛn/, /bjuːˈprfən/,
Namo dagangAdvil, Motrin, Nurofen, others
Namo lainisobutylphenylpropionic acid
AHFS/Drugs.comMonograph
MedlinePlusa682159
Lisensi data
Kategori pado kahamilan
  • D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus
Rute
masuak ubek
by mouth, rectal, topical, and intravenous
Kode ATC
Status legal
Status legal
Farmakokinetik data
Bioavailabilitas80–100% (by mouth),[3] 87% (rectal)
Ikatan protein98%[2]
MetabolismeLiver (CYP2C9)[2]
Metaboliteibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Awitan aksi30 min[4]
Eliminasi wakatu paruah2–4 h[5]
EkskresiUrine (95%)[2][6]
Pangenal
Nomor CAS
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.036.152 Sunting ini di Wikidata
Data kimia jo fisika
FormulaC13H18O2
Molar mass206.29 g/mol g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
Density1.03 g/ml g/cm3
Melting point[convert: $2]$3
Boiling point157 °C (315 °F) at 4 mmHg
Solubility in water0.021 mg/mL (20 °C)
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Ibuprofen marupoan ubek nan digunoan untuak mangurangi raso ngilo jo paradangan, misalnyo sakik gigi, kram kutiko datang bulan, jo radang sandi. Ubek ko tasadio dalam bantuak tablet 400 mg, sirup, jo suntikan.

Rujuakan[suntiang | suntiang sumber]

  1. Kutipan rusak: Tag <ref> indak sah; indak ado teks untuak ref banamo Drugs.com pregnancy
  2. a b c Davies, NM (February 1998). "Clinical pharmacokinetics of ibuprofen. The first 30 years". Clinical Pharmacokinetics. 34 (2): 101–54. doi:10.2165/00003088-199834020-00002. PMID 9515184. 
  3. Davanzo, R; Bua, J; Paloni, G; Facchina, G (November 2014). "Breastfeeding and migraine drugs". European Journal of Clinical Pharmacology (Review). 70 (11): 1313–24. doi:10.1007/s00228-014-1748-0. PMID 25217187. 
  4. "ibuprofen". Diarsipkan dari versi asli tanggal 13 January 2015. Diakses tanggal 31 January 2015. 
  5. Grosser, T; Ricciotti, E; FitzGerald, GA (August 2017). "The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs". Trends in Pharmacological Sciences (Review). 38 (8): 733–48. doi:10.1016/j.tips.2017.05.008. PMC 5676556alt=Dapat diakses gratis. PMID 28651847. 
  6. "Brufen Tablets And Syrup". Therapeutic Goods Administration. 31 July 2012. Diarsipkan dari versi asli (PDF) tanggal 20 August 2016. Diakses tanggal 8 May 2014.