Asetilsistein

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Asetilsistein
Acetylcysteine2DACS.svg
Acetylcysteine 3D.png
Data klinis
Palafalan/əˌstəlˈsɪstin/ and similar (/əˌsɛtəlʔ,_ˌæstəlʔ,_ʔtn/)
Namo dagangAcetadote, Fluimucil, Mucomyst, lainnyo
Namo lainN-acetylcysteine; N-acetyl-L-cysteine; NALC; NAC
AHFS/Drugs.comMonograph
Lisensi data
Kategori pado kahamilan
  • AU: B2
  • US: B (No risk in non-human studies)
Rute
masuak ubek
lewat muluik, injeksi, inhalasi
Kode ATC
Status legal
Status legal
  • AU: S2 (Hanyo apotek)
  • BR: OTC (Over the counter) (lewat muluik, IV, inhalasi)
  • US: OTC (lewat muluik), Rx-only (IV, inhalasi)
Farmakokinetik data
Bioavailabilitas10% (Oral)[2]
Ikatan protein50 hinggo 83%[1]
MetabolismeHati[1]
Eliminasi wakatu paruah5.6 jam[3]
EkskresiRenal (30%),[1] faecal (3%)
Pangenal
Nomor CAS
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.009.545 Sunting ini di Wikidata
Data kimia jo fisika
FormulaC5H9NO3S
Molar mass163.195 g·mol−1
3D model (JSmol)
Specific rotation+5° (c = 3% in water)[5]
Melting point[convert: $2]$3 [5]
  (verify)

Acetylcysteine, tanamo juo jo N-acetylcysteine, adolah ubek nan digunoan untuak maubeki overdosis parasetamol, jo malonggarkan lendir kental pado individu jo fibrosis kistik atau panyakik paru obstruktif kronis. Ubek ko dapek diambiak sacaro intravena, lewat muluik, atau dihiruik sabagai kabuik.

Referensi[suntiang | suntiang sumber]

  1. a b c "Acetylcysteine". The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 23 September 2015. 
  2. Stockley, Robert A. (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management.. Chichester: John Wiley & Sons. p. 750. ISBN 9780470755280. https://books.google.com/books?id=y9li1geShyYC&pg=PA750. 
  3. "ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]". DailyMed. Cumberland Pharmaceuticals Inc. June 2013. Diarsipkan dari versi asli tanggal 13 January 2014. Diakses tanggal 8 November 2013. 
  4. "L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Diarsipkan dari versi asli tanggal 12 January 2014. 
  5. a b "N-ACETYL-L-CYSTEINE Product Information" (PDF). Sigma. Sigma-aldrich. Diarsipkan dari versi asli (PDF) tanggal 11 June 2014.