Asetilsistein

Asetilsistein
Data klinis
Palafalan	/əˌsiːtəlˈsɪstiiːn/ and similar (/əˌsɛtəlʔ,_ˌæsᵻtəlʔ,_ʔtiːn/)
Namo dagang	Acetadote, Fluimucil, Mucomyst, lainnyo
Namo lain	N-acetylcysteine; N-acetyl-L-cysteine; NALC; NAC
AHFS/Drugs.com	Monograph
Lisensi data	US DailyMed: Acetylcysteine; US FDA: Acetylcysteine;
Kategori pado kahamilan	AU: B2 ; US: B (No risk in non-human studies) ;
Rute; masuak ubek	lewat muluik, injeksi, inhalasi
Kode ATC	R05CB01 (WHO) S01XA08 (WHO) V03AB23 (WHO);
Status legal
Status legal	AU: S2 (Hanyo apotek) ; BR: OTC (Over the counter) (lewat muluik, IV, inhalasi); US: OTC (lewat muluik), Rx-only (IV, inhalasi);
Farmakokinetik data
Bioavailabilitas	10% (Oral)
Ikatan protein	50 hinggo 83%
Metabolisme	Hati
Eliminasi wakatu paruah	5.6 jam
Ekskresi	Renal (30%), faecal (3%)
Pangenal
	Namo IUPAC (2R)-2-acetamido-3-sulfanylpropanoic acid;
Nomor CAS	616-91-1 ;
PubChem CID	12035;
DrugBank	DB06151 ;
ChemSpider	11540 ;
UNII	WYQ7N0BPYC;
KEGG	D00221 ;
ChEBI	CHEBI:28939 ;
ChEMBL	ChEMBL600 ;
CompTox Dashboard (EPA)	DTXSID5020021 ;
ECHA InfoCard	100.009.545
Data kimia jo fisika
Formula	C5H9NO3S
Molar mass	163.195 g·mol−1
3D model (JSmol)	Gambar interaktif;
Specific rotation	+5° (c = 3% in water)
Melting point	109 to 110 °C (228 to 230 °F)
	SMILES C/C(=N/[C@@H](CS)C(=O)O)/O;
	InChI InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1 ; Key:PWKSKIMOESPYIA-BYPYZUCNSA-N ;
(verify)

Acetylcysteine, tanamo juo jo N-acetylcysteine, adolah ubek nan digunoan untuak maubeki overdosis parasetamol, jo malonggarkan lendir kental pado individu jo fibrosis kistik atau panyakik paru obstruktif kronis. Ubek ko dapek diambiak sacaro intravena, lewat muluik, atau dihiruik sabagai kabuik.

Referensi

↑ Stockley, Robert A. (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management.. Chichester: John Wiley & Sons. p. 750. ISBN 9780470755280. https://books.google.com/books?id=y9li1geShyYC&pg=PA750.
1 2 3 "Acetylcysteine". The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 23 September 2015.
↑ "ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]". DailyMed. Cumberland Pharmaceuticals Inc. June 2013. Diarsipkan dari versi asli tanggal 13 January 2014. Diakses tanggal 8 November 2013.
↑ "L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Diarsipkan dari versi asli tanggal 12 January 2014.
1 2 "N-ACETYL-L-CYSTEINE Product Information" (PDF). Sigma. Sigma-aldrich. Diarsipkan dari versi asli (PDF) tanggal 11 June 2014.

[1] Stockley, Robert A. (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management.. Chichester: John Wiley & Sons. p. 750. ISBN 9780470755280. https://books.google.com/books?id=y9li1geShyYC&pg=PA750.

[AHFS2015-2] 1 2 3 "Acetylcysteine". The American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 23 September 2015.

[DMI-3] "ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]". DailyMed. Cumberland Pharmaceuticals Inc. June 2013. Diarsipkan dari versi asli tanggal 13 January 2014. Diakses tanggal 8 November 2013.

[4] "L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Diarsipkan dari versi asli tanggal 12 January 2014.

[sial-5] 1 2 "N-ACETYL-L-CYSTEINE Product Information" (PDF). Sigma. Sigma-aldrich. Diarsipkan dari versi asli (PDF) tanggal 11 June 2014.

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